The phrase "a major modification of" is correct and usable in written English.
It can be used when discussing significant changes or alterations made to something, such as a document, plan, or system.
Example: "The committee approved a major modification of the original proposal to better meet the needs of the community."
Alternatives: "a significant change to" or "a substantial alteration of".
A short paper with a major modification of the Carr-Purcell sequence.
The new upgrade represents a "major modification" of the Hawkeye 2000, the version of the plane now in production, Mr. Teel said.
A major modification of its character since the 1920s has been brought about largely by the wider use of mechanical techniques of amplification and recorded music.
The step was a major modification of a White House stance that has limited briefings on the highly classified program to no more than a small group of Congressional leaders, even since the existence of the program was disclosed late last year.
The Act was also a major force behind a major modification of the law criminalizing making false statements.
This is the possibility that a distinct and ancient clade within the hominoids can be identified that share a major modification of axial architecture that underlies the upright posture and primary bipedalism of modern humans.
Phenotypic analysis of various lymphoid organs (spleen, mesenteric, pancreatic lymph nodes) did not reveal any major modification of the T cell compartment as compared to untreated NOD mice (data not shown).
In contrast to the hierarchical cluster analysis this method allows the use of raw normalised data sets without any major modification of the data.
This paper will give details of the Aircraft Engineering teaching programme and describe the first GDP, a major modification programme and flight of the Cranfield A1 Aerobatic Aircraft.
A major modification was that a pair of strain gauges, instead of force transducer, was attached to the beam of footplate for measuring the torque produced by the ankle dorsiflexor as well as plantar flexor muscles, and for reducing the weight of footplate.
We note, however, that if such a modification was a major modification that resulted in the installation of controls, the State will take this into account during the review process and may find that the level of controls already in place are consistent with BART.
