The phrase "a major method to" is correct and usable in written English.
It can be used when discussing significant approaches or techniques to achieve a particular goal or outcome.
Example: "Implementing a major method to improve productivity is essential for the success of our project."
Alternatives: "a key approach to" or "a primary technique for".
Welding is a major method to join thick plates together.
Carbon dioxide Capture and Sequestration (CCS) is a major method to decrease the emissions from centralized large industrial plants.
Global Navigation Satellite System radio occultation (GNSS RO, or in short GRO) has become a major method to observe the Earth's atmospheric thermodynamic state variables, i.e., pressure, temperature, and humidity as retrieved from refraction measurements using the GNSS radio wave signals.
Clustering has been a major method to partition the genes into groups of co-expressed genes [ 23].
Genome-wide gene expression profiling of immune organs or cells has become a major method to simultaneously compare the expression levels of hundreds of thousands of genes between different conditions [ 15– 15].
Clustering is a major method to group districts with similar disease burdens and provide information on which districts are suffering similar syphilis epidemics and should be classified into the same epidemiological region [ 14, 15].
For centuries, peer review has been the major method to determine the fate of an article submitted to biomedical journals.
Regarding regulatory networks, a broad spectrum of methods are dedicated to their analysis although logical modelling remains the major method to take charge of large-scale networks.
Grouting is a major method used to prevent water and mud inrush in tunnels and underground engineering.
Cross-correlation between seismograms of repeating earthquakes (Poupinet et al., 1984; Yamawaki et al., 2004) and those of man-made artificial earthquakes (Nishimura et al., 2005) has been a major method used to detect seismic velocity changes.
Fluorescence microscopy imaging of RNA interference (RNAi) knockdown screens has become a major method of choice to identify the function of the proteins corresponding to the silenced genes and specifically to detect potential drug targets.
