Recent randomized clinical trials and a major meta-analysis have emphasized the importance of LDL-cholesterol (LDL-C) lowering for cardiovascular risk reduction in diabetes mellitus [1] [3].
Also, in a major meta-analysis (Margaliot et al. 2005) of 46 non-randomized studies with either external or internal fixation in 1,519 patients, no clear conclusion could be drawn.
This is in agreement with a major meta-analysis of randomised trials showing that, in the primary setting, chemotherapy in addition to radiation compared with radiation alone was beneficial (Pignon et al, 2000).
In a recent major meta-analysis study, authors from Wirapati et al. (2008) found that estrogen receptor and ErbB2 status were two of only three key prognostic signatures in breast cancer.
All four major meta-analyses gave statistically significant results, favouring a link between high MVD and VEGF expression and poor survival (see Figure 2).
Three major meta-analytic studies have been conducted revealing a number of risk factors strongly associated with PND: a history of depression, antenatal depression, antenatal anxiety, stressful life events, negative cognitive attributional style, low self-esteem, low social support and low income [ 4, 12, 13].
These findings are showcased in two major meta-analyses (Heavey et al., 2013; Park and Shaw, 2013).
Nearly twice as many participants are represented in the current literature than were available at the time of the last major meta-analytic neurocognitive examination of apolipoprotein E (ApoE) epsilon allele combinations [Small, B.J., Rosnick, C.B., Fratiglioni, L., Backman, L., 2004. Apolipoprotein E and cognitive performance: a meta-analysis. Psychol. Aging 19, 592 600].
The increased crash risk with pot alone "is so small you can compare it to driving in darkness compared to driving in daylight," says University of Oslo political scientist Rune Elvik, who conducted several major meta-analyses evaluating the risk of drugged driving.
The increased crash risk with pot alone "is so small you can compare it to driving in darkness compared to driving in daylight," says University of Oslo political scientist Rune Elvik, who conducted several major meta-analyses evaluating the risk of drugged driving.
Actually, we performed four major meta-analyses including studies dealing with either MVD or VEGF expression for both OS and RFS.
