The phrase "a major marker" is correct and usable in written English.
It can be used to refer to a significant indicator or sign of something, often in contexts like research, analysis, or discussions about progress.
Example: "The increase in sales is a major marker of the company's recovery after the recession."
Alternatives: "a significant indicator" or "a key sign".
"If fertilization is no longer a major marker for thinking of the beginning of a person, then where do you go next?" he said, suggesting a better definition might lie in when an embryo develops individuality and a nervous system.
"Pyongyang may have decided now is the time to put down a major marker as Obama's second term approaches and as South Korea elects a new president," he said.
RGS1, a major marker for grain size, was associated with PGWC in 3 environments.
Its high sensitivity and specificity for α-substituted fructosyl amino acids makes the new sensing system ideally suited for the measurement of hemoglobin A1c (Hba1c), a major marker of diabetes.
Dunlop's lead time was over eight seconds outside the lap record given the variable conditions on the circuit but still represented a major marker to the rest of the field.
Thus, nestin is also a major marker of regenerating tissue.
Human PAP is a major histochemical marker for the diagnosis of osteoporosis.
This paper addresses the composition of organic material from the Early Weichselian A-horizons of the Rocourt paleosol, a major paleostratigraphic marker for the Eemian and Early Weichselian in Western Europe.
Occurrences of Laacher See-tephra (LST) at some distance from the eruptive centre have been known since the late 19th century [119], and the potential of the LST to provide a major temporal marker for the Allerød chronozone of the Late Glacial became fully evident as additional and more distal occurrences became known in the latter part of the 20th century [20, 120].
In fact, CEA represents a major tumor marker used widely in the management of colorectal cancer [5] [7].
Further on, owing to the high incidence of CD44s expression in HNSCC its value as a major CSC marker for this specific entity may need to be thoroughly discussed.
