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Discover LudwigThe phrase "a major killer" is correct and usable in written English.
It can be used to refer to something that causes a significant number of deaths or is a leading cause of mortality in a specific context, such as health or safety.
Example: "Heart disease remains a major killer in many countries, affecting millions of people each year."
Alternatives: "a leading cause of death" or "a significant threat to life."
Exact(60)
Flu remains a major killer.
Malaria remains a major killer.
Cancer remains a major killer of mankind.
Cancer is a major killer disease throughout human history.
Diagnosing TB, a major killer, can be cumbersome and inaccurate.
Pneumonia is a major killer of infants and toddlers.
Tuberculosis is a major killer of people with Aids.
Can GM mosquitoes rid the world of a major killer?
YANGON, MYANMAR — Throughout history malaria has been a major killer, particularly in tropical countries.
But in poor countries, measles is a major killer of malnourished infants.
Similarly, data demonstrated that smoking was a major killer decades before the biological processes were understood.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com