The phrase "a major issue that" is correct and usable in written English.
It can be used when introducing a significant problem or concern that will be discussed or elaborated upon.
Example: "Climate change is a major issue that affects ecosystems worldwide."
Alternatives: "a significant problem that" or "a critical concern that".
Public acceptance is a major issue that will determine the future of nuclear energy.
Cautious conservatism is a major issue that threatens the core of medical research.
In IoT networks, congestion is a major issue that causes performance losses or may even render the network useless.
The reproducible preparation of organic crystals in a specific form and size is a major issue that must be addressed.
In spite of decades of progress in the tissue engineering field, vascularization is a major issue that remains unsolved.
However, blind query broadcast is a major issue that leads to the broadcast storm problem in clustered ad-hoc networks.
Researchers and clinicians gathered to explore translational research opportunities and potential collaborations on a major issue that threatens both humans and animals in our region: Lyme disease.
The design and implementation of an efficient and scalable algorithm for information dissemination in VANETs constitutes a major issue that should be tackled.
Prior studies have identified interoperability as a major issue that hinders the adoption of PKI in spite of its effectiveness in implementing strong security mechanisms and protocols.
Today, however, the rise of managed care has helped make doctor-patient communication a major issue that is drawing increasing interest from researchers.
The scheme belongs to the class of desingularized methods, for which the location of singularities and testing points is a major issue that is addressed by the proposed scheme, in the context he 2D Laplace equation.
