The phrase "a major issue due" is not correct and lacks clarity in written English.
It may be intended to indicate that there is a significant problem that is expected or forthcoming, but it needs additional context to be meaningful.
Example: "There is a major issue due to the lack of resources for the project."
Alternatives: "a significant problem arising" or "a major concern resulting".
Fish poisoning has become a major issue, due to increased temperature and acidification of sea-water.
Among other, the relationship, in particular in terms of causality, between symptoms and attachment categories represents a major issue, due to the obvious clinical implications it entails.
For this study of selectivity and ion-exchanging properties, the photostability was not a major issue due to the conversion of the output signal to protonation degree for quantitative evaluation.
The cytotoxicity of these systems remains a major issue, mainly due to their cationic nature.
The removal of these pollutants from sewage and industrial waste water has become a major issue worldwide due to their possible toxic effects.
The cryptocurrency's gains Thursday morning hit new heights, striking well above $18,000 across widely varying exchanges, coming to rest above $16,000 while the popular Coinbase exchange had been suffering major issues due to "record high traffic".
Navigation is a major issue in robotics due to the necessity for the robots' course of movement.
Accuracy of the robot is not a major issue in this project due to the different timescales between the swing and the microcontroller.
Of particular interest to MEMS devices, structural damping has become a major issue affecting dynamic performance due to the various energy dissipation mechanisms involved.
Managing computational effort (CPU time, memory, interfacing) is a major issue in design optimization, due to the cost of the high fidelity numerical simulations (finite elements, finite volumes, etc).
Introduction Weaning from mechanical ventilation is a major issue in intensive care due to the excess mortality implies prolonged ventilation time and reintubation.
