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The phrase "a major issue because" is correct and usable in written English.
It can be used to introduce a significant problem or concern that is being discussed, often followed by an explanation or reason.
Example: "The lack of funding is a major issue because it limits our ability to expand the program."
Alternatives: "a significant problem due to" or "a critical concern as a result of".
Exact(34)
That's a major issue, because you shouldn't have cosmetic surgery when you are like that.
This is a major issue because the integrity of the category suffers with the inclusion of debatable pieces.
"We don't have a major issue, because parents do understand what we are doing, but there are occasions when children get traumatised by the conflict.
The police are doing their job arresting gang members who break the law but gang-related crime is still a major issue because the ideology remains unchallenged.
That is a major issue because one of Pacific Century's largest shareholders, Cable and Wireless of Britain, became free this week to sell half its 15percentt stake.
That is a major issue because it is Lloris's capacity to sweep up behind his defence that allows Spurs to play with a high line.
Similar(26)
An image of an acrocentric chromosome posed a major issue for students, because, students explained, it did not look like something they were used to seeing in a textbook figure.
In the Senate, the deficit looms as a major issue — not because many Republicans are talking about it, but because Republican leaders can afford to lose no more than two of their members, and a handful have expressed concerns about how the overhaul could pile up more debt.
The Gore campaign considers Medicare a major issue partly because it plays well in key states like Florida that have large elderly populations.
The latter represents a major issue also because of the possible southward expansion of the Mediterranean-type climate34 and the invasive nature of Acacia sp35.Furthermore, the threshold in available water (the intersection between the lines in Fig. 4b) could be reached later at the beginning of the wet season in a drier climate, shortening the period of higher net carbon assimilation.
Cyber-bullying is a major issue simply because it causes a great deal of grief and will not subside before it is better understood and before this knowledge is successfully transmitted to users.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com