The phrase "a major interruption in" is correct and usable in written English.
It can be used to describe a significant disruption or break in a process, event, or activity.
Example: "The storm caused a major interruption in the delivery schedule, leading to delays for several days."
Alternatives: "a significant disruption to" or "a substantial break in".
But with the risk of the U.S. military campaign in Afghanistan spilling over into other Islamic nations, specifically into civil war in Saudi Arabia, the possibility that a major interruption in oil supplies from the Persian Gulf exists a scenario that could cause the price of crude to go through the roof.
State workforce agencies have made it through some of briefer lapses without a major interruption in benefits, but NELP estimates that this time, 800,000 people in the federally-funded "Extended Benefits" program, which offers 13 or 20 weeks, depending on the state, will almost immediately stop receiving checks when the program expires.
But this is the last holiday before a major interruption to that world order: both my wife and sister-in-law are pregnant.
Winter weather conditions affect transportation systems in many ways, such as major interruptions in traffic flow, evacuation from transportation systems, and serious impacts on mobility and safety of transportation system users [1].
The 2004 tsunami caused major interruptions in programming as priorities and funding shifted to emergency response.
These days, outdoor holiday decorating has been downsized to a minor interruption in the weekend.
"It's a major business interruption.
The co-operative retailer John Lewis reported that a big effort from "local hero" producers prevented any major interruption of supplies.
Mr. Weitsman kept buying and giving, with one major interruption.
"The external shocks caused major interruptions to reforms in China, particularly the exchange-rate reform".
