The phrase "a major inducer of" is correct and usable in written English.
It can be used when discussing something that significantly stimulates or causes a particular effect or process.
Example: "The study found that stress is a major inducer of various health issues."
Alternatives: "a significant catalyst for" or "a primary trigger of".
Alternatively, indirect regulation mediated by hypoxia-inducible factor-1α, a major inducer of glycolytic genes, may be involved in this phenomenon.
IL12B gene expression is a major inducer of IFNγ and IL12-p40 is required for IFNγ-induced protection from Mtb.
Chronic hyperglycemia that in part can result from glucose intolerance induced by long-term consumption of fructose is a major inducer of vascular complications in diabetes (e.g., heart disease, stroke, blindness, and end-stage renal failure) which are responsible for disabilities and high mortality rates in patients with diabetes.
Furthermore, hypoxia, a major inducer of VEGF in tumors and a characteristic feature of IBC [ 34], induces upregulation of VEGF in mammary fibroblasts [ 35].
TGF-β has been delineated as a major inducer of EndMT (van Meeteren and ten Dijke, 2012).
An intriguing target is the agr quorum-sensing system, which is a major inducer of virulence in CA-MRSA upon activation by agr-encoded staphylococcal autoinducing peptides (AIPs).
To measure mitochondrial content and the expression of estrogen-related receptor-γ (ERRγ, a major inducer of mitochondrial biogenesis) in placentas from women with intrauterine growth restriction (IUGR) associated or not with pre-eclampsia (PE), relative to control placentas.
Transforming growth factor-beta (TGF-β) is a major inducer of EMT [4], [8] and is secreted by various cells including infiltrating immune cells [9], [10].
In addition to being a major inducer of inflammation during innate immune responses, TNF signaling also mediates immunomodulatory effects in adaptive immune responses [29].
