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The phrase "a major inadequacy" is correct and usable in written English.
It can be used to describe a significant flaw or deficiency in something, such as a plan, system, or argument.
Example: "The report highlighted a major inadequacy in the current safety protocols that needed immediate attention."
Alternatives: "a significant shortcoming" or "a critical deficiency."
Exact(1)
Tested cytoprotective drugs aiming to reduce free radical and calcium overloads that occur mainly during ischemic reperfusion are clinically ineffective, reflecting a major inadequacy in targeted damaging factors as differential cell death mechanisms are involved in different kinds of brain cells during ischemia or reperfusion.
Similar(59)
The major inadequacy of the model was that it did not include flow resulting from entanglement slippage, modified in PET by stress-induced crystallization, that intervenes at the upper end of the temperature range.
The major inadequacy of the acute model is that up to 90%[1, 2] heal spontaneously without intervention and therefore accelerating the healing of acute TMP is of little practical value.
However, an additional purpose of this report is to highlight major inadequacies in information systems.
There are major inadequacies internationally in administering appropriate prophylaxis.
"The Ebola epidemic in western Africa overwhelmed fragile health systems, killed thousands of people, and highlighted major inadequacies in our ability to respond to global public health emergencies," said Amy Gutmann, the commission chair.
Nice rumor, he says, before revealing that the size of his Rolodex is a major source of inadequacy issues: what if he breaks a story and can't reach pivotal people for comment?
Perhaps you've been hoping to resolve those inadequacies with a major overhaul.
In summary, the findings illuminate worldwide neglect of a major public-health problem, and reveal the inadequacies of responses to it in countries throughout the world.
WHO wrote, in a message sent inter alia to the world's Ministries of Health: "This first global enquiry into these matters illuminates the worldwide neglect of a major public-health problem, and reveals the inadequacies of responses to it in countries throughout the world" [9].
The inadequacy of public education is a major issue for many urban voters.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com