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The phrase "a major impact when" is correct and usable in written English.
It can be used to indicate the significance of an event or action occurring at a specific time or under certain conditions.
Example: "The new policy will have a major impact when implemented across all departments."
Alternatives: "a significant effect when" or "a substantial influence when".
Exact(6)
But they can only have a major impact when they coincide with serious political and economic crises – and so far it seems that 2008 was not serious enough.
Ernest Borgnine first made a major impact when he played the sadistic Sergeant "Fatso" Judson, who persecutes and later beats to death an Italian private, played by Frank Sinatra, in From Here to Eternity (1953).
"Hopefully he'll have a major impact when he comes back again".
Mr Wetherall said the park had a major impact when play equipment started to appear in local parks.
The placement of wind turbines to improve power output is important but only has a major impact when turbines are in close proximity of one another.
Then, small changes in the delay can have a major impact when the time of quarantine is shifted from just before to just after the end of the latent period, similar to the sensitivity to τlat as observed in Figure 2.
Similar(54)
The investigation of the elderly adult has major impact when defining a control group for assessments in many studies in aged individuals such as in neurodegenerative conditions that commonly manifest in late life.
Patients were excluded if they had ICD-10 codes for additional congenital anomalies or syndromes as these will have a major impact on when and where they may receive their cleft treatment.
Especially, the distances had a major impact on connectivity when it is 3 4 times farther than the radio range.
This has a major impact for example, when compiling the functional descriptors from the GO database.
Demonstrating which of the two interventions tested here is more effective can have a major impact on clinical practice when designing and proposing clinical protocols for the prevention of CRFs.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com