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The phrase "a major impact in" is correct and usable in written English.
It can be used when discussing the significant effect or influence something has on a particular area or subject.
Example: "The new policy is expected to have a major impact in the field of education."
Alternatives: "a significant effect on" or "a substantial influence in".
Exact(60)
"The reforms will not have a major impact in this parliament.
This alone would have a major impact in deterring overseas libel claims.
But the firm is poised to make a major impact in Manhattan.
Platform-based design has had a major impact in research and electronic system design.
Her work has had a major impact in the pharmaceutical industry.
Trastuzumab has had a major impact in the treatment of HER2-positive metastatic breast cancer.
How ever, it could have a major impact in all these applications.
Gates said US aid had "a major impact" in improving agricultural productivity in the world's poorest nations.
In my general assessment of the Katine project, I am not seeing a major impact in the community.
The film's creators say simulating the workings of the heart accurately could have a major impact in medicine.
If the work is valid, however, it could have a major impact in other areas of science.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com