The phrase "a major hallmark" is correct and usable in written English.
It can be used to describe a significant characteristic or feature of something, often in a formal or academic context.
Example: "The ability to adapt to changing environments is a major hallmark of successful species in evolution."
Alternatives: "a key feature" or "a significant characteristic."
Loss of proteostasis has been proposed as a major hallmark of aging [11].
Conversely, the accumulation of altered proteins (proteostatic dysfunction) is a major hallmark of ageing [43].
Spindles are considered as a major hallmark of non REM sleep (NREMS).
Tau plays a critical role in the neurodegenerative process forming neurofibrillary tangles, which is a major hallmark of AD and correlates with clinical disease progression.
Moreover, a major hallmark of cellular senescence is induction of the senescent phenotype which is characterized by secretion of pro-inflammatory factors; thus the condition has been called the senescence-associated secretory phenotype [38].
A major hallmark of the marketing suite when it first launched was a tool called Auto-Engage, which basically allows merchants to incentivize their customers' to return through personalized offers based on their unique buying history.
One of the studies' authors, Nicole Prause, said that "sex addiction" misses another major hallmark of addiction: a person's response to the addictive object over time.
Consequently, brain pathology has been recognised as the major hallmark of HD; for a review see [2].
The death of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD).
The development of DNA sequencing technology four decades ago was a major scientific hallmark and opened the doors for several breakthrough achievements in all areas of biology.
The aggregates of α-synuclein (αS) are a major pathological hallmark of Parkinson's disease (PD) making their structure-function relationship important for rational drug design.
