Sentence examples for a major founder from inspiring English sources

Buckley, a major founder of today's sensible conservatism, has led an extraordinary life, which fully matches his extraordinary talents.

One possible explanation is the presence of two subclones: assuming the seven mutations at higher allelic fraction are present in a heterozygous sate in a major founder clone (28% of the cells, 14% of the DNA) from which a minor clone arose, adding five heterozygous mutations (26% of the cells, 13% of the DNA).

85 A recent GWAS conducted among 38 European patients failed to identify any major founder variant associated with MMD. 90 In Caucasian MMD patients, no association was found between MMD and the p.R4810K variant in RNF213.

Overall, the unique nature of most identified mutations, their uniform distribution throughout the gene, and the presence of de novo cases confirmed that hyperuricemia is not linked to any major founder mutation at least in the Saudi Arabian population but is rather the consequence of multiple, separate, independent events randomly affecting the HPRT gene.

This suggests an absence of successive major founder events at the front of the invaded area during the expansion process or that the effect of dispersal outweighed the effect of genetic drift related to the founder events.

The major founder of the corporation in 1904 05 was Charles M. Schwab, who had earlier been one of the major figures in the creation of United States Steel Corporation (1901).

"A Portrait of the Futurist Marinetti" is three compositions set in ovals featuring the face of Futurism's major founder so faceted that the viewer has to piece it together.

The ages of the major founder types of both West and East African origin are consistent with the likely timing of Bantu dispersals, with those from the west somewhat predating those from the east.

Similar coalescence times were estimated for the other major founder haplogroups - A2, B2 and D1 - suggesting the simultaneous divergence of all founder clades across North and South America.

Even though some additional minor founder types have been later identified in North America, such as X, the hypothesis of just four major founder types in the initial colonization of the New World remains uncontested.

These probably stem from the major founder event during the 16th century migration wave [21] that appears to have affected the gene pool more profoundly than subsequent drift within local population isolates.