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The phrase "a major first step" is correct and usable in written English.
It can be used to describe an important initial action taken towards achieving a goal or making progress in a particular area.
Example: "Implementing the new policy is a major first step towards improving workplace safety."
Alternatives: "a significant initial move" or "an important preliminary action".
Exact(29)
I thank you for taking a major first step.
Encrypting data at rest and in transit is a major first step.
The pact was announced as a major first step for the American effort to win over the tribes.
The SWR1 structure is a major first step towards understanding the functional link between the Rvb1/Rvb2 hexameric ring and dimer exchange.
Getting a previous set of thousands of heliostat coordinates would be a major first step in the complex process of designing solar power tower (SPT).
Critics of the 38-year-old American trade embargo on Cuba hailed the votes as a major first step in the House toward clearing the way to commercial ties and even American tourism.
Similar(31)
"This is a good, major first step," he said.
Therefore, heterologous protein secretion serves as the major first step in recombinant protein purification.
These are both major first steps toward a larger global framework.
Therefore, one of the major first steps toward understanding how tissues achieve their specificity is to identify interacting TFs regulating gene expression in different tissues.
"C" and "E" make a "major" third (two steps).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com