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The phrase "a major factor that" is correct and usable in written English.
It can be used when discussing significant elements or influences in a particular context or situation.
Example: "A major factor that contributed to the project's success was the team's dedication and hard work."
Alternatives: "a key element that" or "a significant influence that".
Exact(60)
A major factor that influences the reliability of science is statistical power.
Histone acetylation is a major factor that affects the degree of chromatin condensation.
"The E.R.T. report was a major factor that delayed everything," he said.
Next year's $60 million salary cap will be a major factor that could restrict trade activity.
The intracellular environment is a major factor that controls these events.
"The facilities part is a major factor that has been overlooked," said J.D. LaRock, a board spokesman.
The study, published in the journal Circulation, suggests poor lifestyle is a major factor that cuts American lives short.
The anion species turned out to be a major factor that influenced the kinetics of the etching process.
The limited availability of imports during the Depression was a major factor that enabled local manufacturing to get its start.
Young's modulus of cement sheath is identified as a major factor that affects the sealing ability of cement sheath.
The representative ability of a calibration set is a major factor that affects the predictive performance of a multivariate regression.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com