The air temperature has been reported to have a negative correlation with amylose content (Asaoka et al. 1985), and was the major factor effecting protein content in rice during the period of 10 20 days after heading (Nakamura et al. 1989).
Results from these simulation studies indicate that a major factor in diluent effectiveness is the differential effect on flame zone residence times associated with fuel-side versus air-side dilution.
A major factor involved in this effect is consumption of unprocessed cow's milk obtained directly from a farm.
As the ISC sample size (about 7000 individuals in total) is smaller than that of either the PGC schizophrenia or bipolar disorder sample, the discovery sample size cannot be a major factor driving the lower effect sizes seen here.
As apoptosis is a major factor for the cytotoxic effects exerted by paclitaxel (Woods et al, 1995; Milross et al, 1996), it might explain why PR-positive tumours were more resistant to paclitaxel compared with PR-negative carcinomas.
Furthermore, we show that DNA-PKcs is a major factor responsible for transducing the effects of HSF1 in HCC cells.
Based on our recent study suggesting that tumour sequestration is a major factor leading to a 'sink effect' that decreases activity concentration in healthy organs such as the kidney [ 28], we hypothesize that giving higher administered activity per cycle particularly in those with larger disease burden may allow greater radiation dose to individual lesions and increased therapeutic index.
HIF-1α protein level is also increased under normoxia downstream of oncogenes and growth factor receptors via mTor-mediated induction of protein translation, which is known to occur downstream of PI3K activation [ 22, 23], and indeed increased HIF-1α activity is recognized as a major factor contributing to the Warburg effect [ 21, 24- 26].
Overall, ES of treatment on daytime and total activity were small, and the large variation in habitual activity between individual dogs is a major factor contributing to small treatment effects in this study, probably acting to increase the magnitude of regression to the mean.
Gregory Schwed New York City Lehrer mentions, but doesn't fully explore, a major factor that leads to a reduced effect in follow-up studies; namely, that effects of a treatment vary across individuals in the population, and consequently depend on the sample included in the study.
