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The phrase "a major factor contributing" is correct and usable in written English.
It can be used when discussing the elements or reasons that play a significant role in a particular outcome or situation.
Example: "The lack of funding was a major factor contributing to the project's failure."
Alternatives: "a significant element influencing" or "a key reason leading to".
Exact(60)
The explosion at Exxon Mobil's huge Torrance refinery a year ago undoubtedly was a major factor contributing to high gasoline prices in California, especially in the Los Angeles area, fuel experts have said.
Health officials say a major factor contributing to outbreaks is a crowded environment.
Inactivity is a major factor contributing to an epidemic of chronic disease.
Carbon dioxide from burning fossil fuels is a major factor contributing to climate change, scientists say.
Female Autonomy has been acknowledged as a major factor contributing to better demographic outcomes.
Quality-of-life issues are a major factor contributing to the current shortage of rabbis and other synagogue professionals.
A major factor contributing to the failure of orthopedic and orthodontic implants is post-surgical infection.
According to the overconfidence hypothesis (OH), physician overconfidence is a major factor contributing to diagnostic error in medicine.
Ineffective myelin debris clearance is a major factor contributing to the poor regenerative ability of the central nervous system.
Listening to the radio at work is a nice perk, but the ordeal of agreeing on a suitable station must be a major factor contributing to workplace stress.
A major factor contributing to the ineffectiveness of warnings is habituation, the decreased response to a repeated warning.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com