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The phrase "a major factor altering" is correct and usable in written English.
It can be used when discussing significant influences or changes in a particular context, such as in research, analysis, or discussions about causes and effects.
Example: "Climate change is a major factor altering weather patterns across the globe."
Alternatives: "a significant element changing" or "a key influence modifying".
Exact(1)
Temperature is a major factor altering grape ripening with high temperatures hastening organic acid metabolisation and inhibiting anthocyanin accumulation [ 8, 9].
Similar(59)
Host immunodeficiency, increasing bacterial resistance to antibiotics, and problematic discrimination of an early onset of infection are the major factors altering the course of infections [ 3, 4].
By Pentagon standards, Admiral McVadon is doveish.In its annual report to Congress on China's military strength, published in May, the Pentagon said China's "expanding military capabilities" were a "major factor" in altering military balances in East Asia.
Hump geometry is a major factor in altering the level of these shocks and specifying the speed limit.
This was reported to be a major factor of altered or reduced foetal growth in sheep [ 27].
For example, generation time, referring to the time to reach sexual maturity, has long been suspected as a major factor that alters the molecular evolutionary rate among species.
However, as obesity in German children was 1.7 times more prevalent than in Poland [ 6], it may have been a major driving factor altering the MODY/type 2 diabetes ratio in the paediatric population.
Altered membrane integrity has been suggested as a major factor in the development of cellular injury during myocardial necrosis.
Inflammation is closely related to altered gene expression of oncogenes and tumor suppressor genes and is a major factor in promoting neoplastic transformation [ 8].
Sun is a major factor.
It will be a major factor — perhaps the major factor.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com