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The phrase "a major extent" is correct and usable in written English.
It can be used to describe the significant degree or level to which something applies or is true.
Example: "The new policy will affect the company's operations to a major extent, leading to changes in workflow and employee responsibilities."
Alternatives: "a significant extent" or "a considerable extent".
Exact(55)
Not to a major extent".
It depends to a major extent on whether the regime places restrictions on her.
From these results it can be concluded that chronic heat stress did not induce oxidative damage to a major extent.
Their biotransformation by various skin bacteria may release aromatic amines (AAs) which might be dermally absorbed to a major extent.
While defeat in battle is, of course, a primary focus of derision in this type of poetry, the honour of the community and the family has resided to a major extent in the protection of its women.
Aaron Black, a leader of the protesters' direct action committee, acknowledged that the movement's First Amendment rights were being protected but said that the protesters' right to assemble had been compromised "to a major extent".
Similar(5)
Hybridization demonstrated interleukin-1-beta mRNA predominantly in macrophages, and not in fibroblasts or in T lymphocytes to any major extent.
In contrast, genes related to leukotriene metabolism were not affected to any major extent.
To the major extent it is caused by difficulties in obtaining suitable samples.
Finally, I obtained them, but only after I managed to rebuild my life to some major extent, with my family's help and my own perseverance, and procure a job that allowed me to finance their purchase.
We show that during this time, the major extent of severe brain cytotoxic edema occurs.
More suggestions(18)
a major significance
a significant extent
a major measurement
a major degree
a major extension
a great extent
a major range
a major proportion
a major size
a major importance
a major magnitude
a highly significant extent
a very considerable extent
a huge extent
a bigger extent
a minor extent
a satisfactory extent
a big extent
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com