The approach we describe takes advantage of protein sequence data, but does not require any knowledge of protein function, a major advantage since the elucidation of function for the majority of Plasmodium genes remains a distant goal.
Previously, the variability in the mechanical properties of natural silk fibers was a major drawback in the elucidation of their behavior, but the authors have found that supercontraction of these fibers allows one to characterize and reproduce the whole range of tensile properties in a consistent way.
As reviewed here, rice has made a major contribution to the elucidation of molecular mechamisms of AM symbiosis, as a model monocot plant.
TAR cloning could become a major tool for functional elucidation of multigene families in P. falciparum.
A number of epidemiological studies have demonstrated that osteoarthritis has a major genetic component, although elucidation of this has proven challenging [ 2].
The use of the visual system played a major role in the elucidation of molecular mechanisms controlling axonal regeneration in the injured CNS after trauma.
Because of the immunomodulatory properties of LMP1 and galectin 9, our observations are expected to have a major impact in the elucidation of host-tumor relationships in NPC patients.
A major breakthrough in the elucidation of the mechanism of protein import into peroxisomes was the identification of the first peroxisomal targeting signal (PTS1) at the C-terminus of luciferase of the firefly Photinus pyralis (Keller et al. 1987; Gould et al. 1987).
Although the aforementioned results make a significant contribution to the understanding of the mechanisms of AT3 fibrillogenesis, the key discovery of the present work is the elucidation of a major, distinctive structural feature arising during the aggregation of the expanded form but not of the normal one, namely hydrogen bonds among glutamine side-chains.
A major focus of this study was elucidation of how important different effector pathways downstream of RAS are in generating the expression profiles exhibited by certain cancer cell lines.
A major challenge for the future is the elucidation of the molecular mechanisms involved in nutrient responses that at least partially depend on metabolism of the nutrient.
