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The phrase "a major effort in" is correct and usable in written English.
It can be used to describe a significant undertaking or initiative in a particular area or field.
Example: "The organization is launching a major effort in environmental conservation to combat climate change."
Alternatives: "a significant initiative in" or "a substantial undertaking in".
Exact(38)
He won, but only after a major effort in a state he once expected to win in a walk.
"Treasury will have to do a major effort in terms of outreach to these small businesses," Mr. Levin said.
New York began a major effort in the 1980s to repair its streets, but that effort peaked in 1999.
But he is better known for a major effort in popular culture -- in 1939 he founded the National Baseball Hall of Fame in Cooperstown.
In 1960, knowing that no Republican had ever won the presidency without carrying Ohio, John F. Kennedy made a major effort in the Buckeye state, holding huge rallies.
But the Pioneers spanned the history of the space age and also of the computer age, occasioning a major effort in what Dr. Turyshev calls "space archaeology".
Similar(19)
"It took a major effort, changes in zoning, and getting legislation passed to make this work," Mr. Deller said.
A major effort is invested in developing specific inhibitory molecules and strategies targeting heparanase [63], [64] and MMPs [65], [66].
I hope that we can all join forces in a major effort, including a financial injection, in order to ensure that everyone is well-informed about this.
A major effort to make a difference in health care in rural areas over this period has been from the NRHM.
"But if Arthur is involved, there must be a major effort to engage the governor in this controversy".
More suggestions(15)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com