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The complexity of the design required a major effort from the Los Alamos Laboratory, and concerns about whether it would work led to a decision to conduct the first nuclear test.
Such strategies require a major effort from national TB programs in terms of laboratory capacity.
However, in type 1 diabetes, as reported by the DCCT, maintaining an A1C less than 7% required a major effort from a dedicated research staff and highly motivated volunteer participants.
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"I'd be very surprised if you see any major effort from the White House to roll back what the Clinton administration has done," said Jerry Taylor, director of natural resources at the Cato Institute, a research and advocacy group in Washington that is opposed to most federal regulation.
In addition to schools changing term lengths, I want to see a major effort, including from local councils, to address the issue of pupils falling behind in the summer.
Though she is susceptible to the upset, it will take a major effort to remove Kvitova from the tournament.
A major effort to sample all habitats from the intertidal zone to the deep sea, including hard-bottom substrata, needs to be undertaken if a true baseline of Canadian marine benthic biodiversity is to be established.
The National Intelligence Council has a major effort under way to analyze threats from water and food shortages related to climate change and other environmental causes, one senior American intelligence official said.
In November 1971, BLM announced a major effort to save the Pryor Mountains herd from starvation after a poor summer growing season left vegetation on the range stunted.
Gurnard rose to periscope depth two hours later and found that a major effort to rescue troops and equipment from the torpedoed transports was under way.
The 1930s saw a major effort to clear the remaining vegetation from the castle, the cellars were cleared of debris by the government's Office of Works and the stable block was converted into a museum.
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