The phrase "a major drawback when" is correct and usable in written English.
It can be used to introduce a significant disadvantage or limitation associated with a particular situation or action.
Example: "A major drawback when using this software is its high learning curve, which can be frustrating for new users."
Alternatives: "a significant disadvantage when" or "a key limitation when".
Contamination with plastid small subunit (SSU) rDNA is a major drawback when analyzing the bacterial communities of plant roots using culture-independent methods.
The results presented here show that post-precursor purge duration is essential when optimizing throughput in temporally separated ALD processes, and that this is a major drawback when considering operation at atmospheric pressure.
The time required for conducting conventional laboratory tests can be a major drawback when the disease has reached crucial stage and faster diagnosis is required.
On the one hand, its Marxist taint became a major drawback when Marxist approaches to history started to collapse and finally went out of fashion in the decades after World War II.
However, one of the disadvantages of this test is its low specificity for AARD [2, 3], which is a major drawback when used in a low disease prevalence population.
Not using a standard to record audit trails represents a major drawback when analysing data and therefore makes it very difficult to use AT to improve HIS.
Currently, one major drawback when performing microarray analyses on data derived from dietary intervention studies is the lack of proper statistical tools.
One of the major drawbacks when using biometrics in mobile devices is the lack of usability being this technology a challenge for users in many cases.
These methods are useful for naturally discrete lists, but have major drawbacks when utilized with continuous gene scores.
Survival analysis is a powerful tool for analysing the results of total joint replacements despite the objections found in the literature [ 8], but it has major drawbacks when the failure rates are very low.
