The phrase "a major dose of" is correct and usable in written English.
It can be used to describe a significant amount of something, often in a figurative sense, such as emotions, experiences, or qualities.
Example: "After the long meeting, I felt like I had received a major dose of motivation to tackle the upcoming project."
Alternatives: "a significant amount of" or "a hefty dose of".
No method can erase the anxiety with which flight phobics must learn to cope, and no method can succeed without a major dose of courage.
(In the wake of the deepest recession since the nineteen-thirties, the last thing the economy needed was a major dose of fiscal austerity).
His incapacitation, even if it proves only short-lived, injects a major dose of drama and uncertainty into the nation's politics.
Great as it is to use Facebook, Instagram, Snapchat and Twitter to stay in touch with friends, it can easily lead to a major dose of envy, paranoia and low self-esteem.
But now we learn that there's a major dose of bad news to accompany that: What's true for carbon dioxide is not at all true for methane, the second most important greenhouse gas.
(In the wake of the deepest recession since the nineteen-thirties, the last thing the economy needed was a major dose of fiscal austerity). But from a traditional Republican point of view the plan was more palatable.
However, the doses prescribed were rather low and we did not see any evidence of a major dose escalations over time.
It is difficult to establish "clean" dose-response effects except for fever and bone marrow suppression, neither of which is a major dose limitation.
Patients receiving myelosuppressive chemotherapy are at risk of developing febrile neutropenia, a major dose-limiting toxicity of systemic chemotherapy associated with hospitalization, use of intravenous antibiotics, and significant morbidity, mortality, and costs [ 1- 10].
Nevertheless, a major dose-limiting toxicity of ABT-263 in patients is apoptosis of platelets that depend on Bcl-xL for their survival.
Peripheral neurotoxicity is a major dose-limiting toxicity of oxaliplatin, which may compromise the delivery and full therapeutic potential of this drug to achieve tumour control or cure.
