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The phrase "a major distinction" is correct and usable in written English.
It can be used when highlighting a significant difference or contrast between two or more subjects.
Example: "There is a major distinction between the two theories that must be addressed in our discussion."
Alternatives: "a significant difference" or "a key contrast".
Exact(60)
A major distinction among descriptions of brain networks is that of structural, functional, and effective connectivity.
The Lavernes maintained that what they did -- screen-printing -- was a handicraft, a major distinction.
To the proud Wakefield, there is a major distinction between those descriptions.
Being granted two slots in the lineup is a major distinction indeed.
Our review confirmed a major distinction between approaches rooted in the natural sciences and approaches rooted in the arts and the humanities.
Importantly, in comparing thermoplastics and poly(dimethylsiloxane) (PDMS), a major distinction between them is that thermoplastics are generally recyclable, while cured PDMS is not.
A major distinction must also be made between conventional bombs and atomic and thermonuclear bombs, which have a far greater destructive capacity.
A major distinction between royal and nonroyal tombs lies in the provision of arrangements for the funerary cult of the deceased.
These reservations can easily comprise 40 70% of the buildable land within each new neighborhood, a major distinction setting this approach apart from previous "clustering" techniques which were rarely utilized in any coordinated way to preserve interconnected open space networks.
A major distinction between water and silicate liquids is that water surrounds dissolved ions with hydration shells, which very likely play an important but still poorly understood role in limiting the isotopic fractionation associated with diffusion.
But there is one thing that unites the new movies coming out of Asia: they are not Hollywood films, a major distinction in a world where alternatives to the big American machine have become unconscionably rare.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com