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The phrase "a major discrepancy between" is correct and usable in written English.
It can be used when discussing significant differences or inconsistencies between two or more items, concepts, or data points.
Example: "There is a major discrepancy between the reported sales figures and the actual revenue generated last quarter."
Alternatives: "a significant difference between" or "a substantial gap between".
Exact(22)
and it is incredibly isolating to find a major discrepancy between the two.
On Sunday night, they held the ball for 57 percent of the match, a major discrepancy between two teams.
Consistent with previous reports, there is a major discrepancy between the actual population within the US and the representation of that population on TV.
Trump's proposal would open up a major discrepancy between the rate for individual taxpayers (35percentt in the new document) and the rate for corporations and businesses (the document calls for 15percentt).
A surprising result from ψ analysis was the presence of parallel folding pathways in all reported studies and a major discrepancy between ϕ and ψ values measured in the same protein.
When they denied it, we purposely presented the story as one of a major discrepancy between what the NSA document claims and what the internet companies claim, as the headline itself makes indisputably clear: The NSA document says exactly what we reported.
Similar(38)
Hence, a major discrepancy exists between potency against PldA relative to the human PLD isoforms of 1000- to 10 000-fold.
Thus, a major discrepancy exists between the widespread detection of C. pneumoniae in atheroma, and the lack of attributable risk in sero-epidemiologic studies.
A major discrepancy exists between the importance given to sample size calculation by funding agencies, ethics review boards, journals, and investigators and the current practice of sample size calculation and reporting.
And Korea sees a major discrepancy in funding between the "hard sciences" and other, more creative coursework, but all of its scores rank among the world's best.
A major discrepancy is apparent between the drug prescription pattern in children and the drugs granted pediatric exclusivity.
More suggestions(15)
a major discordance between
a major disconnect between
a serious discrepancy between
a major dispute between
a major inconsistency between
a broad discrepancy between
a severe discrepancy between
a major imbalance between
a large discrepancy between
a major deviation between
a considerable discrepancy between
a major mismatch between
a major divergence between
a major leap between
a major disjoint between
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com