Sentence examples for a major difficulty was from inspiring English sources

A major difficulty was posed by the incompatibility of the price systems used in the various member countries.

A major difficulty was that, beyond a certain point in most new relationships, condom use could not be sustained.

A major difficulty is access to information and access to resources to help them get into educational institutions".

A major difficulty is that American corporations are governed not only by federal law but also by the rules of the state in which they choose to incorporate.

A major difficulty is the system and computational complexity.

A major difficulty is that both heat and work (not only heat) are involved.

A major difficulty is that every tumor behaves as an organ that evolves in function of its microenvironment.

A major difficulty is the local extrema or multiple solution complication arising from the highly nonlinear nature of the multi-dimensional log-likelihood function.

A major difficulty is whether one and the same science metaphysics can have such two distinct objects as God and creatures, still respecting the principle of the unity of science (DOS 221; see also QLIS 4).

Compared to the space homogeneous case, or more in general to the case of splitting based methods, studied in Dimarco Pareschi [7] a major difficulty is that the local Maxwellian equilibrium state change with respect to time and thus needs a proper numerical treatment.

Despite these efforts, the "form follows function" assertion still remains to be fully understood from a complex network science perspective, a major difficulty being the fact that present network patterns are the result of non-stationary and adaptive evolutionary histories that can greatly vary depending on the network.