Sentence examples for a major difficulty the from inspiring English sources

However, the practical logistics of accessing markets remain a major difficulty – the complexity of drug distribution meant that firms had to rely on building their own networks, which is an expensive and time-consuming endeavor.

That qualifies as a glut, since the last similar live-action project was 1976's The Message, from director Moustapha Akkad – a major difficulty for the aspiring chronicler being the prohibition on depicting the prophet.

Still, lack of substantial fossil evidence of the development of the wing joints and muscles poses a major difficulty to the theory, as does the seemingly spontaneous development of articulation and venation, and it has been largely rejected by experts in the field.

The FCC riser is a complex unit that involves strong multi-variable interactions, complex hydrodynamics and operating restrictions, which poses as a major difficulty in the simulation of the process.

W. V. O. Quine's indeterminacy thesis of radical translation presents a major difficulty for the explanations of the conceptual content and meaning of terms in Yoruba language provided by the onisegun to Hallen and Sodipo.

However, a major difficulty in the use of SUA is the difficulty in isolating the same neurons over time [7], [10].

A major difficulty in the numerical treatment of FDEs is the presence of the long and persistent memory, which is related to the nonlocal nature of fractional derivative operators.

Currently, a major difficulty in the interpretation of these data, regarding the effects of the disorder per se, is the lack of comparison to the normal state of the basal ganglia.

A major difficulty in the study of random XCI is the small size of the embryo and the limited amount of material available at this stage.

A major difficulty with the data set lies in the difference of data collection with respect to contacts at work.

A major difficulty in the analysis of SMNs is the assembling of large numbers of survivors who have been followed up over sufficiently long periods of time with a wide spectrum of treatments.