The phrase "a major difficulty for" is correct and usable in written English.
It can be used when discussing a significant challenge or obstacle faced by someone or something.
Example: "The lack of funding has become a major difficulty for the research team in completing their project on time."
Alternatives: "a significant challenge for" or "a considerable obstacle for".
In addition, patent rights remained a major difficulty for the industry.
This poses a major difficulty for a reliable interpretation of geochemical results.
Loss to follow-up (LTFU) can be a major difficulty for any clinical research study.
A major difficulty for time discretization comes from the nonlinear behavior of the kinetic energy of the system.
But choosing which ICT systems they should invest in - some of which they may not yet fully understand - can be a major difficulty for teachers.
Interpreting this result has been a major difficulty for integrating topology optimization and shape optimization into an automated structure design procedure.
A major difficulty in utilizing the SFE for biomolecules has been the difficulty in measurement and prediction of their solubilities in supercritical solvents at various pressures and temperatures for process optimization.
A major difficulty in getting sensible solutions for mental health sufferers is that a unduly generous system would be exploited by scamsters and even ordinary people with irresponsible tendencies.
The rapid death of patients led to a major difficulty in finding living patients for questionnaires: patients' relatives are interviewed, which can induce a bias in responses.
A major difficulty in developing new drugs for the treatment of cancer is the limited specificity of these compounds, which often also affect non-tumor cells.
Thus, the absence of a robust commercial market is a major difficulty, resulting in slow progress for research and development of new influenza vaccines and in dangerously thin supply lines.
