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The phrase "a major difficulty because" is correct and usable in written English.
It can be used to introduce a significant challenge or obstacle that is linked to a specific reason or cause.
Example: "The project faced a major difficulty because of the lack of funding, which hindered progress."
Alternatives: "a significant challenge due to" or "a considerable obstacle as a result of".
Exact(1)
A 3D simulation of turbulent flow and coupled heat transfer between the working fluids poses a major difficulty because the range of length scales involved in heavy-duty radiators varies from few millimeters of the fin pitch and/or tube cross-section to several meters for the overall size of the radiator.
Similar(59)
It has a major difficulty, however, because it frequently experiences quality problems such as longitudinal curvature.
However, selecting the initial temperature for calculating accumulated temperature has been a major difficulty in bioclimatology because it may differ substantially in plants of the same species when influenced by varying environmental factors (Heide 1993; Murray et al. 1989).
It is a major difficulty to produce the 1 13 phase because of its low phase stability at elevated temperatures and low atomic diffusivity [11,12].
A major difficulty we encountered was enumerating the homeless population mainly because it lacked a common definition.
A major difficulty of the subspace iteration method with shift is that because of singularity problem, a shift close to an eigenvalue cannot be used, resulting in slower convergence.
A major difficulty is how to accurately validate the results of PET imaging because it is not possible to biopsy all abnormal sites identified.
Lighting is a major difficulty.
It just feels like a major difficulty in life".
"P14 now explains perfectly a major difficulty which we couldn't understand," Dr. McCormick said.
It gets messy towards the end, where Cusk overcomplicates the plot and ducks a major difficulty.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com