The phrase "a major difference of" is not correct in standard written English.
It is typically used to indicate a significant distinction between two or more things, but the preposition "of" is not appropriate in this context.
Example: "There is a major difference between the two approaches to problem-solving."
Alternatives: "a major difference between" or "a significant difference in".
The announcement of Sisu taking control at Coventry came eight weeks later and within three days Southampton's chief executive, Jim Hone, the chairman, Ken Dulieu, and the commercial director, Andy Oldknow, had quit, blaming "a major difference of opinion between them and certain major shareholders".
There is a major difference, of course.
There is also a major difference of opinion on defence spending.
In the murine heart we demonstrate a major difference of the left ventricular uptake in favor of MIBI at all time points when using tail vein injections.
High viscosity and high density are the most prominent properties of heavy crude oil, resulting in a major difference of rheology feature with the conventional oil.
We see at once from Figure 5 that a major difference of the two charge distributions is the presence of an effective central charge in the case of HT-AT while the core region is essentially neutral for HT-T.
In none of the models has the defect been described as located outside of the umbilical ring, which constitutes a major difference to that of the human phenotype.
As she discussed, when women negotiate salary, the pay gap shrinks -- not completely, but significantly, and enough to make a major difference for many of us.
These results suggest that for a minor impost, employers can make a major difference to the lives of their employees.
"She made a major difference to a lot of people's lives through the care she gave them and her teaching.
In our approach, calculation of the MI/log-likelihood score is done in a manner which is similar to the approaches in MIT/MDL, with a major difference: calculation of score (using MI/log-likelihood) in case of joint regulation.
