The phrase "a major difference is that" is correct and usable in written English.
It can be used to highlight a significant distinction between two or more subjects or ideas.
Example: "When comparing the two theories, a major difference is that one emphasizes individual behavior while the other focuses on societal influences."
Alternatives: "a key distinction is that" or "a significant contrast is that".
A major difference is that instead of using a human mutated transgene that is not relevant to the disease, rats express a truncated form of the normal human tau protein.
A major difference is that birds don't really have tails, or if they do, they're fairly naff, feathery things.
A major difference is that reflexology locates these pressure or reflex points only in the hands and feet.
A major difference is that the Senate would continue the $70 million taxpayer subsidy of the Tennessee Valley Authority, which the House would end.
A major difference is that the Republican Party's dramatic abandonment of its low-spending, decentralist and voluntarist principles is much more recent than the FDU's.
"A major difference is that in this case, cold means 70 million degree Celsius". The gas clouds are in the core of a galaxy cluster known as Abell 2142.
However, a major difference was that instead of using a single muscle promoter like we did in our study they used endogenous promoters.
She said that she had worked with terminal cancer patients and that a major difference was that AIDS commonly affected younger men at an age when many were not prepared to face disability, decline and death.
A major difference was that beetles, especially T. castaneum, were captured far less frequently in traps away from storage in India than in Australia, a pattern that needs to be confirmed before a biological basis for it is sought.
Prawer was often asked to comment on this analogy, and claimed that a major difference was that the Jews settled the land and worked it, whereas the Crusaders lorded over a conquered land worked by the natives.
A major difference was that our gene models were MAKER-based, while those of C. capitata were produced using JAMg (http://jamg.sourceforge.net).net
