The phrase "a major difference exists between" is correct and usable in written English.
You can use it when discussing distinctions or contrasts between two or more subjects or concepts.
Example: "A major difference exists between traditional education and online learning in terms of student engagement."
Alternatives: "a significant distinction can be found between" or "a key difference lies between".
These results confirm that a major difference exists between information obtained from cultured cells in- vitro and analysis of tumoral tissues.
Furthermore, a major difference exists between vaccine usage in the national cattle population and study herds.
A major difference exists between these two backgrounds, that is, a second wave of vertebrate-specific expansion of protein families involved in signaling, such as cytokines involved in immune response (fig. 5 D), which "dilutes" the original enrichment signal.
Unlike the three functional categories described above, for which a major difference exists between their relative distribution in the list of 189 selected antigens as compared to that in the whole genome, a similar fractional distribution is observed in both lists with respect to the functional categories: Intermediary metabolism and respiration and the Cell wall and cell processes.
Several major differences exists between the Dutch consensus guideline for the diagnosis of chronic Q fever and the alternative criteria.
In this study, we showed that major differences exist between and even within lineages regarding the different types of TEs present in the mobilome.
However, major differences exist between genes whose expression is altered in response to a given stress vs. those needed for resistance to the stress (Giaever et al. 2002; Thorpe et al. 2004; Berry and Gasch, 2008; Mitchell et al. 2009).
For CR and TS, the major differences exist between the adopter group and other groups.
The outlook for substantive financial regulatory reform remains poor, as major differences exist between the Dodd approach and the House measures.
In organisational dimension, the major differences exist between adopter (mean 3.89) and rejecter (mean 2.73) and between planning to adopt group (mean 3.36) and rejecter (mean 2.73).
However, major differences exist between mechanically ventilated newborn rats and premature born infants.
