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The phrase "a major development in" is correct and usable in written English.
It can be used to describe a significant change or advancement in a particular field or area of interest.
Example: "The discovery of a new vaccine represents a major development in the fight against infectious diseases."
Alternatives: "a significant breakthrough in" or "a substantial advancement in".
Exact(59)
A battery-powered HMD device that isn't attached to a PC or mobile phone would definitely be a major development in an industry largely dominated by developer and consumer devices situated at either end.
503bffc5-5757-465b-99c9-7b5578c63cc4 BBC mexplainsorrespondent Fergus Walshowxplains how British scientists have used a new technique to develop a synthetic virus which heralds a major development in vaccines.
Next week may bring a major development in another field.
MWB has already undertaken a major development in Docklands.
A major development in the new survey concerned the smartphone.
A major development in national journalism took place, and the status of women improved.
Mr. Rivera called Mr. Padernacht's support a major development in the campaign.
Rowling's solicitor, Keith Schilling, said: "This case is a major development in the law of privacy in this country".
McDonald's is offering UK staff on zero-hours contracts the option of moving to fixed hours in a major development in the debate about employee rights.
Philippe Sands, who was interviewing Clegg at the Guardian Hay festival, described this as a "major development" in an article for Comment is Free.
Wednesday's deal to secure the release of Sally Faulkner and four Channel Nine staff is a major development in the sorry story of a custody dispute gone global.
More suggestions(16)
a major growth in
a tremendous development in
a broad development in
a main development in
a considerable development in
a serious development in
a momentous development in
a major evolution in
a large development in
a large scale development in
a major lapse in
a welcome development in
a major cut in
a major enterprise in
a significant development in
a major role in
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com