The phrase "a major constriction of" is correct and usable in written English.
It can be used when discussing significant limitations or restrictions in various contexts, such as economics, biology, or policy.
Example: "The new regulations resulted in a major constriction of the company's ability to expand its operations."
Alternatives: "a significant limitation of" or "a substantial restriction of".
For HLA donor centers/registries the cost of HLA typing currently is a major constriction limiting the resolution and number of loci typed at registration.
The only question was what kind of business she would start — a tricky question considering that Li was facing a very major constriction.
The conduit system of mature karstified carbonate aquifers is typically characterised by a high hydraulic conductivity and does not impose a major flow constriction on catchment discharge.
Greed is a deprivation of abundance, a hoarding, a constriction of energy.
Such a finding provided two pieces of information: (i) L7 lines the central constriction, and (ii) OccK1 ΔL7 undergoes a major alteration of the tight loop packing characterized by its contacts with loop L3.
The results obtained in vivo with the noninvasive method indicated a major role of vagal M2 receptors in inhibiting airway constriction.
The functional space occupied by dung beetles in oil palm showed major constrictions (Fig. 3), indicating a marked reduction or complete loss of some functional traits.
Actomyosin filaments are also a major component of the contractile ring and play an important role in the constriction of the ring during cell division.
A major function of their contractility appears to be to decrease the capacity of the cardiovascular system by constriction of the peripheral vessels in response to the heart's inability to pump sufficient blood.
ET-1 production is controlled by a number of soluble factors, including TGF-β, which is a well recognized major profibrotic factor, and it plays a major role in constriction and proliferation.
