The phrase "a major constriction" is correct and usable in written English.
It can be used in contexts discussing significant limitations or restrictions in various fields, such as medicine, engineering, or economics.
Example: "The study revealed a major constriction in the blood vessels, which could lead to serious health complications."
Alternatives: "a significant limitation" or "a substantial restriction."
The only question was what kind of business she would start — a tricky question considering that Li was facing a very major constriction.
Most authorities would agree that a vowel is a sound that is produced without any major constrictions in the vocal tract, so that there is a relatively free passage for the air.
The conduit system of mature karstified carbonate aquifers is typically characterised by a high hydraulic conductivity and does not impose a major flow constriction on catchment discharge.
The two major constriction filters corresponding to the two NPA motifs and the ar/R filter were shown in Figure 1.
Two conidial separation mutants, Δ csp-1 and Δ csp-2, form major constriction chains with double crosswalls in developing conidiophores but no free macroconidia (Selitrennikoff et al. 1974).
The aquaporin channel posses two major constriction zones, the NPA region, located at the centre of the pore and the selectivity filter (SF) containing the aromatic/arginine region, (ar/R), located ~8 Å above the NPA region extending towards the extracellular side of the channel.
The functional space occupied by dung beetles in oil palm showed major constrictions (Fig. 3), indicating a marked reduction or complete loss of some functional traits.
ET-1 production is controlled by a number of soluble factors, including TGF-β, which is a well recognized major profibrotic factor, and it plays a major role in constriction and proliferation.
Considering that the Y-27632 effectively protects the organ-cultured artery against FBS-induced gradual arterial constriction (Figure?2B), inhibition of the downstream signaling of upregulated RhoA/ROCK may be a major cause for preventing arterial constriction even in higher expression of RhoA and ROCK.
