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The phrase "a major consequence of" is correct and usable in written English.
It can be used to indicate a significant result or effect that arises from a particular cause or action.
Example: "The new policy was implemented, and a major consequence of this change was an increase in employee satisfaction."
Alternatives: "a significant result of" or "a key outcome of".
Exact(60)
But, as this individual response ignores pensioners without household wealth, it will only serve to reinforce existing generational and social inequality – a major consequence of which is the increase in poor households and child poverty – rather than promote social mobility.
A major consequence of land reform, however, was that the reform agencies run by central politicians in Rome became economically dominant in many rural areas, controlling, among other things, land allocation, loans, and improvement grants.
It is a major consequence of the principle of mutuality of obligations that the duties of seller and buyer must be performed in general at the same time unless the parties agree otherwise.
As we all know, a major consequence of technology over the last many years has been to erode institutions of authority and shelter us in bubbles of personal truths.
A major consequence of lactate secretion is microenvironmental acidification.
Posture changes are a major consequence of IS (IS).
Early death due to hemorrhage is a major consequence of traumatic injury.
A major consequence of this approximation is that the resulting solver can deal with any Equation Of State.
A major consequence of non-stoichiometricity of cementite is the reduced value of the Curie temperature (up to 17 °C) with respect to that of the equilibrium compound.
Yet it turned out, as a major consequence of the Vienna Circle's protocol-sentence debate (see Uebel 2007), that this criterion was far too strict.
A major consequence of the application of DNA typing is that it has led to the discovery and characterization of many new alleles.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com