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The phrase "a major concern about" is correct and usable in written English.
It can be used when discussing significant issues or worries related to a specific topic or situation.
Example: "There is a major concern about the impact of climate change on global food security."
Alternatives: "a significant worry regarding" or "a primary issue with".
Exact(42)
A major concern about genetically modified crops is transgene flow through pollen dispersal.
A major concern about outsourcing healthcare data is its associated privacy issues.
A major concern about house arrest is whether it is cost-effective.
With no access to food, prolonged displacement, limited humanitarian access, there's a major concern about it.
A major concern about this plan right now is the amount of sodium it contains.
However, because they exhibit excellent initial joint strength when tested in standard climate conditions, there has not been a major concern about their service durability.
Similar(18)
That is a major concern I have about not only real estate, but the overall economy.
Habitat loss today is a major concern; only about 100 remain in the wild.
My detailed remarks are listed here: Figure 1: a major concern is about the proper tissue handling when using Hypoxyprobe.
A major concern was about the seemingly disparate results presented in our studies (Dikomey et al, 1998, 2000; El-Awady et al, 2003).
I guess we have all been sort of depressed in the sense of a lack of a national major concern about education.
More suggestions(15)
a great concern about
a fundamental concern about
a major valley about
a major conference about
a general concern about
a huge concern about
a major case about
a major revamp about
a major shareholder about
a strong concern about
a legitimate concern about
a major intersection about
a major newspaper about
a major announcement about
a critical concern about
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com