The phrase "a major complicating" is not complete on its own but can be part of a correct and usable expression in written English.
It can be used when discussing factors that significantly complicate a situation or issue.
Example: "The lack of funding is a major complicating factor in the project's timeline."
Alternatives: "a significant obstacle" or "a key challenge".
A major complicating factor is that in 1905, before the boundary was settled, the two states entered into a compact that is still in effect.
Protein receptor rearrangements upon ligand binding are a major complicating factor in structure-based drug design.
Iranian-backed militias are already a major complicating factor in the Western-backed campaign to retake territory from ISIS, and Iran's support for Syrian President Bashar Assad's regime has helped prolong the nation's civil war.
In this setting, aging per se is a strong predictor of hypoglycemia [ 102- 104] and hypoglycemia, in turn, is a major complicating factor of antidiabetic treatment [ 105].
Successful treatment of the pulmonary hypertension depends on the rapidity with which the physician treating the underlying disease recognises that pulmonary hypertension is a major complicating factor in the clinical picture.
Psychosocial treatments for cocaine dependence, which include cognitive behavioural therapy, counselling and relapse prevention, have generally produced modest results [ 6, 7], and both study data and practice-based experiences indicate that poor compliance is a major complicating factor in these treatments.
The idea of having a global forum for religious groups has been around for a century but has come up against major complicating factors -- questions of authority, how to deal with conflicting ideas about ultimate truth and what to do about proselytism.
Oxygen consumption is a major factor, complicating the use of oxygen as a tracer gas.
A major obstacle complicating the introduction of SCS into the clinical environment is the lack of onsite oncologists or physicians who sufficiently understand the sequencing results and are able to translate those results into clinical action.
The development of multiresistant bacteria (MRB) nosocomial infections has raised a major problem complicating the care of combat casualties [ 1].
Despite advanced technology and new insulin analogs, the fear of hypoglycemia is still a major problem complicating the management of diabetes (4, 5).
