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A major complexity in treating retinal degenerations is retinal remodeling: pathologic network rewiring, molecular reprogramming, and cell death that compromise signaling in the surviving retina.
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Second, there are major complexities in accessing the rights to content as well as fulfillment.
Although experimental data reveal major complexities in carbonate phase diagrams, and natural occurrences highlight extreme compositional variability, these series have been mostly regarded as simple binary mangesite-siderite, and dolomite-ankerite solid solutions, the latter eventually coexisting with calcite/aragonite.
Descriptive characterizations have been obtained for many of the major complexity classes considered in Section 3, several of which are summarized in Table 2.
The question of whether PTIME can be characterized by a logic of the form FO* Q) remains open, however (indeed, solving it would be a major breakthrough in complexity theory).
Nevertheless in suspension ALMS and control fibroblasts displayed similar dimensions (Figure 1e), whereas two of the mutated ones possessed a major cellular complexity (Figure 1f,g and Figure S3).
A single haploid megagametophyte offers a major reduction in sequence complexity although at the expense of constraining the amount of DNA available.
For example, UTR lengths are correlated with gene function, localization and requirements for regulation [ 5]; alternative splicing plays a major part in biological complexity in humans [ 6]; and non-coding RNAs (ncRNA) are crucial for multiple biological processes [ 7, 8].
Intriguing in this respect is the fact that the rise of oxygen levels in the late Proterozoic (about 0.85 - 0.54 Gya) [ 92] is also correlated with a major transition in eukaryote complexity involving sex; i.e., the evolution of multicellular body plans containing meiosis-specialized germ lines [ 98].
The performance achieved through MIMO technology also entails a considerable increase in signal processing complexity in receiver, and there exists a major challenge in designing low-complexity receivers for multichannel wireless systems.
Moreover, in studies seeking to also study the factors relevant to accurate diagnosis, these patients may present with comorbid conditions or contextual complexities that are not representative of typical patients, and case complexity is a major factor in determining diagnostic accuracy.
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