Sentence examples for a major clinical issue from inspiring English sources

The occurrence of brain metastasis is a major clinical issue.

Identification of patients with high-risk of recurrence is therefore a major clinical issue.

Resistance to chemotherapy remains a major clinical issue in the treatment of colorectal cancer (CRC).

Resistance to chemotherapy remains a major clinical issue in the treatment of colorectal cancer (CRC) and other cancers.

The history of multiple tumors, that is, whether they derive from a common precancerous or cancerous ancestor or individually from hepatocytes, is a major clinical issue.

From the perspective of healthcare providers, therapeutic compliance is a major clinical issue in RA patients as it impacts disease's outcomes [ 5, 17, 18].

Obviously, for these patients the major clinical issue would be to rule out cancer.

Featuring contributions from leading clinician-scientists, Aging and Heart Failure: Mechanisms and Management is an authoritative resource on the major clinical issues in heart failure therapy in the elderly for cardiologists, gerontologists and internists.

Here we report only major clinical issues concerning the management of advanced non-small-cell lung cancer (NSCLC).

These harms were rare and mild, and unlikely to be major clinical issues.

Nutrition and gastrointestinal function are also major clinical issues in RTT, and there is marked growth failure in most affected individuals (Tarquinio et al., 2012).