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The phrase "a major changing of" is not correct in standard written English.
It is typically used in contexts discussing significant transformations or shifts in a particular area, but the phrasing is awkward.
Example: "The organization is undergoing a major changing of its policies to adapt to new regulations."
Alternatives: "a major shift in" or "a significant change in".
Exact(3)
In November when ITV finally bought out the last remaining GMTV minority shareholder, Disney, and took editorial control, it was clear there would be a major changing of the guard, on and off screen.
"It really is a major changing of the guard, and this is the end of the Kennedy dynasty," Darrell M. West, a Brookings Institute scholar and author of "Patrick Kennedy: The Rise to Power".
The departures next year of Senators Tom Harkin of Iowa, Frank R. Lautenberg of New Jersey, John D. Rockefeller IV of West Virginia and Carl Levin of Michigan will result in a major changing of the guard in a body once known for stability and longevity.
Similar(56)
Greater accessibility to hitherto forbidden public spaces has become a major source of changing internal domestic gender planning and design relationships.
A beneficiary can obtain relief from the surcharge by showing that the I.R.S. data was incorrect or that the person's income declined because of a "major life-changing event" like the death of a spouse or the loss of pension benefits.
Especially when you're talking about a major life-changing event, the kind of thing both people involved have to enter into in absolute harmony.
So while the RTTT has been "sold" as a major game-changing investment or "bailout" of public schools, local school districts know better.
Over the coming years we expect to keep investing in sustainable assets, keeping an eye on technology, policy, and other trends that are a major part of our changing world.
But for working class women, decent childcare can be life changing, removing a major source of social stress and bringing to an end a common form of drudgery.
This is a major result of our paper: changing a purely spatial characteristics (here the positions of the genes) is enough to change the system dynamics in a qualitative manner (from oscillatory to stationary).
However, due to the success of anti-retroviral treatment (ART), HIV is changing from a major cause of death among young adults and children to a chronic condition with which the patients may survive into middle age and beyond.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com