The phrase "a major causal factor" is correct and usable in written English.
It can be used when discussing the primary reasons or influences behind a particular outcome or event.
Example: "In the study, researchers identified a major causal factor in the rise of obesity rates among children."
Alternatives: "a significant contributing factor" or "a key determinant".
The evidence in their work suggests strongly that inequality is a major causal factor contributing to these costly outcomes.
Driver drowsiness has been implicated as a major causal factor in road accidents.
I believe the column "Yet Another Reminder: Forget the Suntan" put a bit too much emphasis on sunlight as a major causal factor for melanoma.
Results support that Lp(a) may be a major causal factor for precipitating mechanisms of accelerated progression of cardiovascular disease (CVD).
Either way, the students got a prompt response, and there was no statistically significant difference in the level of enthusiasm, leading the researchers to conclude: "It is unlikely that discrimination is a major causal factor accounting for professorial liberalism".
Rather, they suggest that the severe flooding of the Danube and its tributaries was a major causal factor in the Goths' surrender.
If incomplete target inhibition driven by autocrine ligand induction can mediate resistance to a selective inhibitor, such as lapatinib, then induction of ligand-driven autocrine feedback loops in response to promiscuous kinase inhibitors may be a new major causal factor of resistance.
Our analysis revealed that ground shaking seems to be the major causal factor of earthquake-related changes in groundwater but that the acceleration of this ground shaking cannot always explain the observed groundwater level changes.
Smoking is considered as the major causal factor of chronic obstructive pulmonary disease (COPD).
For the tumors of the meninges, increasing trends were observed around the world [ 13, 17, 19, 21- 231]31], and improvements in the diagnostic technologies are still considered to be the major causal factor.
These results suggest that the role of STAT5 in CD4+ T cell survival and proliferation is unlikely the major causal factor of EAE resistance in Stat5-conditional knockout mice.
