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This was a major breakthrough.
"It was a major breakthrough".
A major breakthrough in gene therapy.
Mantell's realisation was a major breakthrough.
This would represent a major breakthrough in regenerative medicine.
Finding hubs in Hollywood was a major breakthrough.
The machine represents a major breakthrough in costs.
"That was a major breakthrough in the profession," she said.
"It's early days to portray this as a major breakthrough.
The process, Dr. Higgins said, is "a major breakthrough".
He said the settlement was a major breakthrough.
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