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The phrase "a major bottleneck when" is correct and usable in written English.
It can be used to describe a significant obstacle or hindrance that occurs during a specific situation or process.
Example: "The lack of communication between departments created a major bottleneck when trying to complete the project on time."
Alternatives: "a significant obstacle during" or "a critical hindrance when".
Exact(1)
Third, the use of BEDTools mitigates the need to interact with local or public instances of the UCSC Genome Browser or Galaxy, which can be a major bottleneck when working with large genomics datasets.
Similar(59)
Although catalytic activity was initially the major bottleneck, when the blue dimer was one of the few available homogeneous catalysts that could perform water oxidation, major breakthroughs have been realized in the past few years.
Both ways are acceptable, however, when data size is increasing, the application processing becomes a major bottleneck.
The route remained unchanged until the 1980s when the Hanford Roundabout junction had a flyover built, as this was a major bottleneck for both the A500 and A34.
For Windows users, viruses can also be a major bottleneck for online connections.
But a major bottleneck ahead of him on the road to stardom saw him choose a different route altogether.
That would eliminate the lag time in retrieving data from the hard disk, a major bottleneck in current computers.
New Jersey commuter trains share a 100-year-old tunnel with Amtrak, a major bottleneck.
The station now is a major bottleneck that causes serious delays.
Yet implementation is likely to remain a major bottleneck, especially in rural communities, where societal cohesion and harmony often override the impersonal, costly criminal justice system.
This caused a major bottleneck.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com