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Discover LudwigThe phrase "a major blockage" is correct and usable in written English
It can be used to describe a significant obstruction or hindrance in various contexts, such as medical, logistical, or metaphorical situations. Example: "The construction work on the main road has caused a major blockage, leading to significant traffic delays."
Exact(3)
The mound turns into a major blockage, the artery closes, and eventually a stroke or a heart attack is triggered.
After a few days, the man with Medicaid went to the hospital, had an abnormal EKG and an emergency angiogram, which revealed a major blockage and required immediate angioplasty.
We were unable to perform similar steady-state kinetics experiments for FAAF because this lesion caused a major blockage at the replication fork.
Similar(57)
There is also plenty of evidence pointing to "certainty" rather than "uncertainty" as being currently the major blockage on new investment: the certainty, that is, of a lack of demand in consumer markets kept impoverished by the very austerity packages so favored by the conservative economists wedded to the Republican cause.
Sajjad Karim MEP Lib Dem, North West England The 96 economists urging further movement at the WTO to help the poorest countries (Letters, October 10 ) fail to mention the major blockage in the talks - the huge levels of agricultural subsidies enjoyed by the USA and the European Union, while agricultural tariff cuts are demanded of poorer countries.
Because today, the single biggest hindrance - the major blockage that makes both HEARING and ACCEPTING Shinran's Dharma "the most difficult of all difficulties" - is the proliferation of false teaching coming from those who claim to be speaking in Master Shinran's name - and yet are saying (and believing) something ENTIRELY different from what Master Shinran said and believed.
Running start experiments were specifically carried out to determine the overall impact on the rate of full length primer extension across the lesion and the major blockage sites for polymerase.
Both lesions strongly blocked at the lesion site (n); however, they exhibited similar sequence effects, i.e., the G*C A sequence exhibited a greater extension efficiency compared to that of G*C T. With Dpo4, the lesions stalled primer extension only at n – 1 and n, but the major blockage site occurred at n – 1 for FABP, compared to n for FAF.
Primer extension experiments showed major blockage of all three pols one nucleotide prior to the first dG of the cross-link; only pol I was able to incorporate a nucleotide opposite the first dG with no incorporation being detected opposite the second cross-linked dG.
For years, people who suffered heart attacks but didn't have major blockages in their arteries — a condition called myocardial infarction with nonobstructive coronary arteries (MINOCA) — were thought to have a less serious form of heart disease.
Dpo4 extended the primer to a full-length 44-mer and displayed major blockages at n – 1 and n.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com