Sentence examples for a major and difficult from inspiring English sources

The restrictions arrived as party leaders signaled new curbs on China's short-message, Twitter-like microblogs, an Internet sensation that has mushroomed in less than two years into a major — and difficult to control — source of whistle-blowing.

A major and difficult task is the design of clinical trials with a time to event endpoint.

In hindsight, we have to admit that we were quite slow in appreciating that Cryptosporidium infection in a renal transplant patient is a major, significant and difficult to treat, complication, rather than a temporary episode of diarrhoea with an unusual pathogen.

To date, no research has addressed the major and difficult-to-answer question of the ideal treatment for an individual patient from the health services perspective, i.e. the treatment with the lowest cost of extra health gains.

In the event of a major pandemic, difficult decisions regarding the use of scarce resources will need to be made, and explicit planning ahead for the pandemic is advised.

Specified the sensitivity and complementary sensitivity functions are a major difficult point in this method because the conflict of the functions.

Have you gone through a major challenge or difficult period in your relationship and come out the other side?

But winning a major is incredibly difficult.

Roger Federer is three wins from making more history here at Flushing Meadows, a sixth US Open title and an 18th major, and it is difficult to see even the unpredictable Gaël Monfils posing him many problems in the quarter-finals on Wednesday, although it will not be dull.

I respect Marissa Mayer for running a major company and making sometimes difficult decisions.

However, diagnosing TB promptly and accurately remains a major challenge and is even more difficult in extrapulmonary TB as the tests available have poor sensitivity and specificity.