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The phrase "a major alternative" is correct and commonly used in written English.
It means a significant or important alternative to something else. Example: "After considering all the options, I decided to pursue a major alternative - studying abroad instead of staying at my local university."
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An exon 12 alternatively spliced BRCA2 transcript has previously been described as a major alternative BRCA2 transcript with an expression level of about 10% in normal breast tissue relative to the wild type BRCA2 transcript.
Meanwhile, as Israel grew more prosperous and traffic between Jerusalem and Tel Aviv heavier, the road, known as Highway 443, became a major alternative to Israeli commuters.
"For some countries it's an incredible source of diversity of supply and for other countries it could be a major alternative to coal for incremental demand," he said.
With its emphasis on content and free form, Surrealism provided a major alternative to the contemporary, highly formalistic Cubist movement and was largely responsible for perpetuating in modern painting the traditional emphasis on content.
The Ukraine crisis has strengthened Iran's hand in its nuclear talks and other dealings with the west by reminding European countries and the Obama administration of its potential as a major alternative energy supplier if Russia cannot be relied upon, officials and analysts in Tehran say.
"YouTube has become a major alternative distribution point for jihadi propaganda, especially for homegrown militants who may not have the pedigree to gain access to the classic password-protected jihadi chat forums," Mr. Kohlmann said, referring to militant sites that restrict access.
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Back in the 1980s, the New Music Seminar was a major alternative-music convention in New York, an annual bash that drew more than 6,000 people and, in the days before the Internet, let talent scouts for record labels get a look at hundreds of emerging bands at dozens of nightclubs.
It is highly unlikely that this situation may have prevented the detection of a second factor – the major alternative for a unidimensional model.
Several 2006-2007 LBOs default on their bonds, taking down a couple of major alternative investment houses and causing tens of billions in new write-offs at our banks.
The origins of CAF were revised by Orimo and Weinberg, who suggested three major alternative hypotheses: a) genetic alteration, b) an activation without genetic alteration of normal tissue fibroblasts, and c) the activation of bone marrow-derived mesenchymal stem cells (MSC) [ 96].
Past city administrations have shown little faith that, if nurtured, bicycling could grow into a major transportation alternative; and they have been loath to force motorists to cede even a small part of their dominion over our streetscape.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com